Periodic acid-schiff-positive megaloblasts in pernicious anemia.

Abstract

Periodic acid-Schiff-positive material representing glycogen was found in bone marrow megaloblasts at all stages of maturation from 11 patients with severe untreated pernicious anemia. This accumulation of glycogen in megaloblasts, which are known to have disordered biosynthesis of DNA, RNA, and histones, suggests that carbohydrate metabolism may also be abnormal in vitamin B12 deficiency, perhaps as a result of an abnormality in the enzyme amylophosphorylase.

• Authors: L Kass
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 67 Issue 4 Pg. 371-3 (Apr 1977) ISSN: 0002-9173 [Print] England
• PMID: 265681 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Glycogen

Topics

• Anemia, Pernicious (metabolism, pathology)
• Bone Marrow (pathology)
• Bone Marrow Cells
• Erythrocytes, Abnormal (pathology)
• Glycogen (metabolism)
• Humans
• Leukemia, Erythroblastic, Acute (pathology)
• Megaloblasts (metabolism, pathology)
• Periodic Acid-Schiff Reaction