Abstract |
The pharmacokinetic properties of sarafloxacin were investigated after single intravenous (i.v.) and oral (p.o.) administration of 10 mg/kg body weight (b.w.) in allogynogenetic silver crucian carp at 24-26 °C. The plasma concentrations of sarafloxacin were determined by high-performance liquid chromatography. After i.v. administration, the plasma concentration-time data were described by an open two-compartment model. The elimination half-life (T(1/2β)) was estimated to be 22.58 h. The volume of distribution, V(d(area)), was estimated to be 5.95 L/kg, indicating good tissue penetration of sarafloxacin in the fish. Area under the concentration-time curve (AUC) and total body clearance of sarafloxacin were 56.86 µg·h/mL and 0.18 L/h/kg, respectively. Following p.o. administration, the maximum plasma concentration (C(max)), T(1/2β), and AUC of sarafloxacin were 0.79 µg/mL, 46.68 h, and 16.58 µg·h/mL, respectively. Absorption of the drug was not good with a bioavailability (F) of 29.15%. Based on a minimum inhibitory concentration (MIC) of 0.00625 to 0.045 μg/mL for susceptible strains, sarafloxacin p.o. administration at a dose 10 mg/kg could be efficacious against common pathogenic bacteria of fish.
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Authors | Xingxing Fang, Jianguo Zhou, Xiuhong Liu |
Journal | Fish physiology and biochemistry
(Fish Physiol Biochem)
Vol. 42
Issue 1
Pg. 335-41
(Feb 2016)
ISSN: 1573-5168 [Electronic] Netherlands |
PMID | 26563280
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Ciprofloxacin
- sarafloxacin
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Topics |
- Administration, Intravenous
- Administration, Oral
- Animals
- Anti-Bacterial Agents
(administration & dosage, blood, pharmacokinetics)
- Biological Availability
- Carps
(blood, metabolism)
- Ciprofloxacin
(administration & dosage, analogs & derivatives, blood, pharmacokinetics)
- Models, Biological
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