Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: CONCLUSIONS: The expression of WNT5A in a group of odontogenic lesions suggests the participation of a non-canonical WNT signaling pathway in the progression and maintenance of these lesions. These molecules are possibly involved in the biological differences between odontogenic tumors and cysts. Considering previous studies, WNT5A may help promote the calcification seen in AOT, CCOT and CEOT by activating MMP7.
|
Authors | Douglas Magno Guimarães, Daniella Moraes Antunes, Juvani Lago Saturno, Fabiola Massuda, Katiúcia Batista da Silva Paiva, Fabio Daumas Nunes |
Journal | Acta histochemica
(Acta Histochem)
Vol. 117
Issue 8
Pg. 667-74
(Oct 2015)
ISSN: 1618-0372 [Electronic] Germany |
PMID | 26558991
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Elsevier GmbH. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Proto-Oncogene Proteins
- WNT5A protein, human
- Wnt Proteins
- Wnt-5a Protein
- MMP20 protein, human
- Matrix Metalloproteinase 20
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Ameloblastoma
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Child
- Female
- Humans
- Immunohistochemistry
- Jaw Neoplasms
(metabolism)
- Male
- Matrix Metalloproteinase 20
(metabolism)
- Middle Aged
- Mouth Mucosa
(metabolism, pathology)
- Proto-Oncogene Proteins
(metabolism)
- Wnt Proteins
(metabolism)
- Wnt-5a Protein
- Young Adult
|