Abstract | INTRODUCTION: METHODS: A total of 20 patients, of mean age 72 ± 10 years, were enrolled in this open-label, multicenter clinical study. Exploratory statistical data analysis was performed with descriptive interpretation of intra-individual comparisons using simple univariate statistics. RESULTS: The diagnosis of HIT was confirmed in 16 subjects by an independent scientific committee. Fourteen patients (70 %) were in an intensive care unit during the course of the study. Patients were treated with argatroban for a mean duration of 8.5 ± 6.1 days. The mean starting dose of argatroban was 0.77 ± 0.45 μg/kg/min. Platelet recovery was rapid. aPTT and anti-IIa activity assays were used to monitor the dose of argatroban. The mean baseline aPTT value was 45.0 ± 9.8 sec and increased to 78.2 ± 35.8 sec two hours after initiating argatroban. At this time mean argatroban concentration was 0.34 ± 0.16 and 0.61 ± 0.28 μg/ml using ECT and TT measurements, respectively. New and/or extended thromboses were reported in 25 % of patients and major bleedings were documented in 15 %. Six patients died due to their underlying medical condition. CONCLUSION: Considering its hepatic elimination and its short half-life, argatroban can be considered as a safe therapeutic option in HIT patients at high hemorrhagic risk and with renal failure, particularly in an ICU setting.
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Authors | Brigitte Tardy-Poncet, Philippe Nguyen, Jean-Claude Thiranos, Pierre-Emmanuel Morange, Christine Biron-Andréani, Yves Gruel, Jérome Morel, Alain Wynckel, Lelia Grunebaum, Judith Villacorta-Torres, Sandrine Grosjean, Emmanuel de Maistre |
Journal | Critical care (London, England)
(Crit Care)
Vol. 19
Pg. 396
(Nov 11 2015)
ISSN: 1466-609X [Electronic] England |
PMID | 26556106
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticoagulants
- Pipecolic Acids
- Sulfonamides
- Heparin
- Arginine
- argatroban
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anticoagulants
(therapeutic use)
- Arginine
(analogs & derivatives)
- Female
- Heparin
(adverse effects)
- Humans
- Male
- Middle Aged
- Partial Thromboplastin Time
- Pipecolic Acids
(therapeutic use)
- Platelet Count
- Sulfonamides
- Thrombocytopenia
(chemically induced, drug therapy)
- Treatment Outcome
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