Seasonal Variation in the Incidence of Late-onset Bleb-related Infection After Filtering Surgery in Japan: The Japan Glaucoma Society Survey of Bleb-related Infection Report 3.

Abstract

PURPOSE:

To investigate seasonal variations in the incidence of late-onset bleb-related infection after filtering surgery in Japan and the relationship between season and other factors.

PATIENTS AND METHODS:

This multicenter, prospective study is part of a 5-year-long Japan Glaucoma Society survey of bleb-related infection. We analyzed 156 cases of first-time infections (106 men, 50 women) encountered over 5 years to determine the seasonal variation using the Roger test and the relationships between season, sex, and age by logistic regression analysis.

RESULTS:

We noted significant monthly seasonal variation in the incidence of infection, which was the highest in January and February (23 and 18 infections, respectively; P=0.018) and lowest from August to November (9, 9, 11, and 8 infections, in that order). Multiple logistic regression analysis revealed that infections were most frequent among women in spring (odds ratio, 8.43; P=0.005). Staphylococcus aureus and Streptococcus spp. infections were more frequent in warmer seasons than in winter. Less virulent species, namely, coagulase-negative Staphylococcus spp., Corynebacterium spp., and Enterococcus spp., were frequently detected in winter. Coagulase-negative Staphylococcus spp. and Haemophilus influenzae were more frequent in women and men, respectively.

CONCLUSIONS:

The incidence of late-onset bleb-related infection showed significant seasonal variation and sex differences. The climate in Japan may influence the incidence of bleb-related infection. Moreover, besides climate, physical activity level and lifestyle may contribute to the seasonal variation in the incidence and sex differences in the involved bacterial agents of bleb-related infections in Japan.

• Authors: Hideto Sagara, Tetsuya Yamamoto, Tetsuju Sekiryu, Masashi Ogasawara, Toshiro Tango
• Journal: Journal of glaucoma (J Glaucoma) Vol. 25 Issue 1 Pg. 8-13 (Jan 2016) ISSN: 1536-481X [Electronic] United States
• PMID: 26550963 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Adult
• Age Distribution
• Aged
• Anti-Bacterial Agents (therapeutic use)
• Bacteria (isolation & purification)
• Eye Infections, Bacterial (drug therapy, epidemiology, microbiology)
• Female
• Filtering Surgery (statistics & numerical data)
• Glaucoma (surgery)
• Health Surveys
• Humans
• Incidence
• Intraocular Pressure
• Japan (epidemiology)
• Male
• Middle Aged
• Ophthalmology (organization & administration)
• Prospective Studies
• Risk Factors
• Seasons
• Sex Distribution
• Societies, Medical (statistics & numerical data)
• Surgical Wound Infection (drug therapy, epidemiology, microbiology)