Abstract | PURPOSE: To compare the histopathological features and survival of triple-negative breast carcinomas (TBNC) in younger and older women. METHODS: We documented 312 patients with TBNC between 2008 and 2013. The histopathological and clinical features of women who were 35 years old or younger (N=53) were compared to those of women who were 60 years old and older (N=58). Patients were administered adjuvant or neoadjuvant chemotherapy, and adjuvant radiotherapy. RESULTS: We diagnosed and treated a total of 312 patients with TNBC. The median follow-up was 38 months (mean ±SD:37.36; range: 0.2-383.4). The median age of the younger patients was 32 years (mean ±SD:31.6 ± 3.72; range:19-36) and of older patients 67 years (mean ±SD: 68.21 ± 6.78; range:60-84). The tumor size in young patients was larger than in older patients (p=0.001). More comorbid diseases were observed in older patients than in younger ones (p=0.001). There was no difference in the histological grades, lymphovascular invasion, stage and nodal involvement between the two groups. Local / distant metastases were found in 11 (40.7%) patients in the young patient group and in 16 (59.3%) in old patient group (p=0.704). Three (5.4%) patients died from each group. No significant difference in terms of disease-free survival (DFS) and overall survival (OS) (p=0.914, p=0.939, respectively) was noticed. CONCLUSION:
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Authors | Nilufer Bulut, Kadri Altundag |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2015 Sep-Oct
Vol. 20
Issue 5
Pg. 1276-81
ISSN: 1107-0625 [Print] Cyprus |
PMID | 26537075
(Publication Type: Journal Article)
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Topics |
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Female
- Humans
- Middle Aged
- Triple Negative Breast Neoplasms
(mortality, pathology, therapy)
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