Abstract | AIM: METHODS: A total of 682 patients enrolled in the Target Temperature Management (TTM) trial, surviving >24h with available IL-6 data were included. IL-6 was measured on days 1, 2 and 3 after return of spontaneous circulation. Severity of PCAS was assessed daily by the Sequential Organ Failure Assessment score. Survival status was recorded at 30 days. RESULTS: High levels of IL-6 at day 1-3 (all p<0.0001) were independently associated with severity of PCAS with no interaction of target temperature (all p=NS). IL-6 levels did not differ between temperature groups (p(interaction)=0.99). IL-6 levels at day 2 (p<0.0001) and day 3 (p<0.0001) were associated with crude mortality. Adjusted Cox proportional-hazards analysis showed that a two-fold increase of IL-6 levels at day 2 (HR=1.15 (95% CI: 1.07-1.23), p=0.0002) and day 3 (HR=1.18 (95% CI: 1.09-1.27), p<0.0001) were associated with mortality. IL-6 levels at day 3 had the highest discriminative value in predicting mortality (AUC=0.66). IL-6 did not significantly improve 30-day mortality prediction compared to traditional prognostic factors (p=0.08). CONCLUSIONS: In patients surviving >24h following cardiac arrest, IL-6 levels were significantly elevated and associated with severity of PCAS with no significant influence of target temperature. High IL-6 levels were associated with increased mortality. Measuring levels of IL-6 did not provide incremental prognostic value.
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Authors | John Bro-Jeppesen, Jesper Kjaergaard, Pascal Stammet, Matthew P Wise, Jan Hovdenes, Anders Åneman, Janneke Horn, Yvan Devaux, David Erlinge, Yvan Gasche, Michael Wanscher, Tobias Cronberg, Hans Friberg, Jørn Wetterslev, Tommaso Pellis, Michael Kuiper, Niklas Nielsen, Christian Hassager, TTM-Trial Investigators |
Journal | Resuscitation
(Resuscitation)
Vol. 98
Pg. 1-8
(Jan 2016)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 26525271
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Biomarkers
(blood)
- Coma
- Comorbidity
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Hypothermia, Induced
(methods)
- Interleukin-6
(blood)
- Male
- Middle Aged
- Organ Dysfunction Scores
- Out-of-Hospital Cardiac Arrest
(blood, mortality, therapy)
- Predictive Value of Tests
- Prognosis
- Survival Rate
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