A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows.

Abstract

Ovarian follicular cysts are anovulatory follicular structures that lead to infertility. Hormones play key roles in the formation and persistence of cysts. Inhibins are heterodimeric gonadal glycoprotein hormones that belong to the transforming growth factor-β superfamily. These hormones suppress the secretion of follicle-stimulating hormone. In this report, partial fragment of inhibin-α (INHA) subunit gene of Large White pig was detected from the genomic DNA by polymerase chain reaction. The sequence showed a 283 bp fragment insertion/deletion (I/D) polymorphism in INHA subunit gene. A total of 49 Large White sows with cystic follicles and 152 normal sows were screened for this polymorphism. The relationship of INHA I/D polymorphisms with follicular cysts was investigated. The distribution of I/D was significantly different between cystic and normal sows, thereby suggesting that the INHA subunit gene might be a potential biological marker for breeding programs in pig.

• Authors: Wanhong Li, Shuxiong Chen, Hongjiao Li, Zhuo Liu, Yun Zhao, Lu Chen, Xu Zhou, Chunjing Li
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 78 Issue 3 Pg. 473-6 (May 18 2016) ISSN: 1347-7439 [Electronic] Japan
• PMID: 26521695 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• inhibin-alpha subunit
• Inhibins

Topics

• Animals
• Biomarkers
• Female
• Follicular Cyst (genetics, veterinary)
• Inhibins (genetics)
• Mutagenesis, Insertional
• Polymorphism, Genetic
• Sequence Deletion
• Swine
• Swine Diseases (genetics)