Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.

Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

• Authors: Daniela E Kirwan, Cesar Ugarte-Gil, Robert H Gilman, Luz Caviedes, Hasan Rizvi, Eduardo Ticona, Gonzalo Chavez, José Luis Cabrera, Eduardo D Matos, Carlton A Evans, David A J Moore, Jon S Friedland, Lymph Node TB Working Group, Peru
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 54 Issue 1 Pg. 185-9 (Jan 2016) ISSN: 1098-660X [Electronic] United States
• PMID: 26511739 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Kirwan et al.

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Bacteriological Techniques (methods)
• Female
• Humans
• Male
• Microscopy (methods)
• Middle Aged
• Sensitivity and Specificity
• Time Factors
• Tuberculosis, Lymph Node (diagnosis)
• Tuberculosis, Multidrug-Resistant (diagnosis)
• Young Adult