Effect of pentoxifylline in proteinuric chronic kidney disease: a systematic review and meta-analysis.

Abstract

AIM:

The aim of this study was to assess the effect of pentoxifylline on proteinuria and renal function in chronic kidney disease (CKD) treatment.

METHODS:

We systematically searched PubMed, EMBASE, the Cochrane Library and ClinicalTrials.gov for randomized and non-randomized controlled trials comparing pentoxifylline to placebo, no treatment or renin-angiotensin system blockade in proteinuric CKD patients. The outcomes concerning proteinuria, renal function, blood pressure and adverse events were extracted.

RESULTS:

Twelve trials with 613 participants were identified. Pentoxifylline significantly decreased proteinuria [weighted mean difference (WMD) -0.60 g/day (95 % CI -0.84 to -0.36); p < 0.001] compared to placebo or no-treatment groups, but the decrease was not significant [WMD: 0.10 g/day (-0.34 to 0.54); p = 0.66] compared to captopril treatment. The decrease of glomerular filtration rate was significantly less [WMD: 3.67 ml/min (2.71-4.62); p < 0.001] in the pentoxifylline group than in the controls. There was no significant difference in serum creatinine [WMD: -0.03 mg/dl (-0.10 to 0.03); p = 0.28], diastolic blood pressure [WMD: 0.94 mmHg (-0.74 to 2.61); p = 0.27] and adverse events [RR: 0.89 (0.60 to 1.32); p = 0.56].

CONCLUSIONS:

Pentoxifylline may decrease proteinuria and protect renal function in patients with CKD. Further studies are needed to confirm this result.

• Authors: Xiangpin Jiang, Shengguo Zhou, Jing Yao, Xianglei Kong, Meiyu Cui
• Journal: Journal of nephrology (J Nephrol) Vol. 29 Issue 5 Pg. 653-62 (Oct 2016) ISSN: 1724-6059 [Electronic] Italy
• PMID: 26510426 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Phosphodiesterase Inhibitors
• Urological Agents
• Pentoxifylline

Topics

• Chi-Square Distribution
• Glomerular Filtration Rate (drug effects)
• Humans
• Kidney (drug effects, physiopathology)
• Odds Ratio
• Pentoxifylline (adverse effects, therapeutic use)
• Phosphodiesterase Inhibitors (adverse effects, therapeutic use)
• Proteinuria (diagnosis, drug therapy, physiopathology, urine)
• Renal Insufficiency, Chronic (diagnosis, drug therapy, physiopathology, urine)
• Risk Factors
• Treatment Outcome
• Urological Agents (adverse effects, therapeutic use)