Abstract | BACKGROUND: METHODS: The animal model was established by injection with 50 % CCl4 subcutaneously in male wistar rats twice a week for four weeks. Meanwhile, EPP and EPS were administered orally every day for 4 weeks, respectively. The protective effects of EPP and EPS on biochemical metabolic parameters, liver function, oxidative markers, activities of antioxidant enzymes and liver fibrosis were determined in CCl4-induced liver toxicity in rats. RESULTS: CONCLUSION: The EPP and EPS have protective effects against liver fibrosis induced by CCl4, and its mechanisms might be associated with their antioxidant activity, the ability of decreasing the level of TGF-β1 and inhibition of collagen synthesis.
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Authors | Xiang-Lan Wei, Ru-Tang Fang, Yong-Hua Yang, Xue-Yuan Bi, Guo-Xia Ren, A-Li Luo, Ming Zhao, Wei-Jin Zang |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 15
Pg. 389
(Oct 27 2015)
ISSN: 1472-6882 [Electronic] England |
PMID | 26508316
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Plant Extracts
- Carbon Tetrachloride
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Topics |
- Animals
- Biomarkers
(metabolism)
- Carbon Tetrachloride
- Disease Models, Animal
- Liver
(drug effects, metabolism, pathology)
- Liver Cirrhosis
(chemically induced, metabolism, pathology, prevention & control)
- Liver Function Tests
- Lythraceae
(chemistry)
- Male
- Oxidative Stress
(drug effects)
- Plant Extracts
(pharmacology)
- Rats
- Rats, Wistar
- Seeds
(chemistry)
- Spleen
(metabolism)
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