Abstract |
Vascular endothelial growth factor ( VEGF) undergoes alternative splicing to produce both proangiogenic and antiangiogenic isoforms. Preferential splicing of proangiogenic VEGF is determined by serine- arginine protein kinase 1 (SRPK1), which is upregulated in a number of cancers. In the present study, we aimed to investigate SRPK1 expression in prostate cancer (PCa) and its association with cancer progression. SRPK1 expression was assessed using immunohistochemistry of PCa tissue extracted from radical prostatectomy specimens of 110 patients. SRPK1 expression was significantly higher in tumour compared with benign tissue (p<0.00001) and correlated with higher pT stage (p=0.004), extracapsular extension (p=0.003) and extracapsular perineural invasion (p=0.008). Interestingly, the expression did not correlate with Gleason grade (p=0.21), suggesting that SRPK1 facilitates the development of a tumour microenvironment that favours growth and invasion (possibly through stimulating angiogenesis) while having little bearing on the morphology or function of the tumour cells themselves.
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Authors | Nicholas Bullock, Jonathan Potts, Andrew J Simpkin, Anthony Koupparis, Steve J Harper, Jon Oxley, Sebastian Oltean |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 69
Issue 2
Pg. 171-5
(Feb 2016)
ISSN: 1472-4146 [Electronic] England |
PMID | 26500332
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ |
Chemical References |
- Angiogenic Proteins
- Biomarkers, Tumor
- SRPK1 protein, human
- Protein Serine-Threonine Kinases
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Topics |
- Adult
- Aged
- Angiogenic Proteins
(analysis)
- Biomarkers, Tumor
(analysis)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Predictive Value of Tests
- Prostatectomy
- Prostatic Neoplasms
(enzymology, pathology, surgery)
- Protein Serine-Threonine Kinases
(analysis)
- Risk Assessment
- Risk Factors
- Treatment Outcome
- Tumor Microenvironment
- Up-Regulation
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