Abstract | BACKGROUND: METHODS: The aim of this study was to screen for the presence of antibodies reacting with RNA polymerase III (anti-RNAP3) in a large cohort of patients with SSc treated at a tertiary referral center and to evaluate correlations with disease severity. RESULTS: Anti-RNAP3 antibodies were detected in 11 of 158 patients (7.0%). Eight of the 11 (72.7%) anti-RNAP3-positive patients had diffuse cutaneous SSc (P < 0.01). A higher modified Rodnan skin score, associated with diffuse SSc, correlated with the presence of anti-RNAP3 (P < 0.0001). The detection of anti-RNAP3 antibodies strongly correlated with the presence of renal involvement (P < 0.0001). The odds ratio of RNAP3-positive patients to develop renal involvement was 80.1 (95% CI 9.3-690.1). CONCLUSIONS: This study demonstrates that the detection of anti-RNAP3 antibodies in patients with SSc correlates with renal crisis and severe cutaneous involvement. The possibility to detect specific antibodies with a prognostic value can lead to a better risk management of patients with SSc.
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Authors | Sarah Terras, Hans Hartenstein, Stefan Höxtermann, Thilo Gambichler, Alexander Kreuter |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 55
Issue 8
Pg. 882-5
(Aug 2016)
ISSN: 1365-4632 [Electronic] England |
PMID | 26499848
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2015 The International Society of Dermatology. |
Chemical References |
- Autoantibodies
- Biomarkers
- RNA Polymerase III
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Topics |
- Adult
- Aged
- Autoantibodies
(analysis, immunology)
- Biomarkers
(metabolism)
- Chi-Square Distribution
- Cohort Studies
- Disease Progression
- Female
- Follow-Up Studies
- Germany
- Humans
- Kidney Diseases
(epidemiology, immunology, physiopathology)
- Male
- Middle Aged
- RNA Polymerase III
(analysis, immunology)
- Retrospective Studies
- Risk Assessment
- Scleroderma, Diffuse
(epidemiology, immunology, physiopathology)
- Scleroderma, Limited
(epidemiology, immunology, physiopathology)
- Scleroderma, Systemic
(immunology, physiopathology)
- Severity of Illness Index
- Skin Diseases
(epidemiology, immunology, physiopathology)
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