Abstract | BACKGROUND: OBJECTIVES: The aim of this study was to evaluate the expression of VEGF and EGFR in ovarian cancer in southern Iran and to assess the correlation between expression of these two markers and patients' age, tumor stage, and grade. PATIENTS AND METHODS: RESULTS: A significant difference in the frequency of positive expression of VEGF was observed in ovarian cancer patients (25.0%) compared with the control group (8.0%) (P = 0.023). A significant difference between EGFR expression in patients (56.8%) and controls (24.0%) was also obtained (P = 0.001). No significant correlation between VEGF and EGFR expression and patients' age, tumor grade and stage were detected (P > 0.05). CONCLUSIONS: The significant increase in both VEGF and EGFR in the patients with ovarian cancer compared to healthy individuals could have prognostic value. Identifying these markers may be useful for chemopreventive and chemotherapeutic strategies for patients with serous ovarian cancer.
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Authors | Reza Ranjbar, Foroogh Nejatollahi, Ahmad Sina Nedaei Ahmadi, Hossein Hafezi, Akbar Safaie |
Journal | Iranian journal of cancer prevention
(Iran J Cancer Prev)
Vol. 8
Issue 4
Pg. e3428
(Aug 2015)
ISSN: 2008-2398 [Print] Iran |
PMID | 26478789
(Publication Type: Journal Article)
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