Abstract | OBJECTIVE: METHODS: RESULTS: Six months after initiating the ketogenic diet, it was effective (greater than a 50% reduction in seizure frequency) in 31.6% of patients. We did not find a link between rate of efficacy for the ketogenic diet and etiologies of epilepsy, nor did we find a link between the rate of efficacy for the ketogenic diet and cerebrospinal fluid pterins and biogenic amines concentrations. However, we found statistically significant differences for lysine and arginine values in the cerebrospinal fluid between ketogenic diet responders and nonresponders, but not for the other amino acids analyzed. SIGNIFICANCE:
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Authors | Andrea Sariego-Jamardo, Angels García-Cazorla, Rafael Artuch, Esperanza Castejón, Dolores García-Arenas, Marta Molero-Luis, Aida Ormazábal, Francesc Xavier Sanmartí |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 53
Issue 5
Pg. 422-6
(Nov 2015)
ISSN: 1873-5150 [Electronic] United States |
PMID | 26476148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Amino Acids
- Neurotransmitter Agents
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Topics |
- Age of Onset
- Amino Acids
(cerebrospinal fluid)
- Child, Preschool
- Diet, Ketogenic
- Drug Resistant Epilepsy
(cerebrospinal fluid, diet therapy, etiology)
- Epilepsies, Partial
(cerebrospinal fluid, diet therapy, etiology)
- Humans
- Neurotransmitter Agents
(cerebrospinal fluid)
- Seizures
(cerebrospinal fluid, diet therapy, etiology)
- Treatment Outcome
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