Using a quantitative standardized procedure, the swelling of the ankle produced by supination
trauma was measured. In the 66 patients with fresh
rupture of the lateral ligament treated surgically at our Department between December 1986 and April 1987, a prospective study of the effect of
serrapeptase (Aniflazym) on post-operative swelling and
pain was carried out in 3 randomized groups of patients. In the group receiving the test substance, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg,
bed rest, with and without the application of
ice) no reduction in swelling had occurred at that time. The difference is statistically significant (p = 0.013). Decreasing
pain correlated for the most part with the reduction in swelling. Thus, the patients receiving the test substance more rapidly became
pain-free than did the control groups. On the basis of these results,
serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of
ice.