Abstract | OBJECTIVES: MATERIALS AND METHODS: Diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (STZ) and confirmed by blood glucose level higher than 250 mg/dl. After confirmation of diabetes, crocin (30 mg/kg, i.p.), safranal (1 mg/kg, i.p.) (alone or in combination with insulin) and insulin (5 IU/kg, s.c.) were administered for eight weeks. Neuropathic pain was evaluated using acetone drop test. Histopathological changes of sciatic nerve were evaluated using light microscope. Blood glucose levels and sciatic nerve malondialdehyde (MDA) contents were also measured. RESULTS: STZ caused cold allodynia, edema and degenerative changes of sciatic nerve, hyperglycemia and an elevation of sciatic nerve MDA levels. Crocin, safranal and insulin improved STZ-induced behavioral, histopathological and biochemical changes. Combined treatments produced more documented improving effects. CONCLUSION:
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Authors | Amir Abbas Farshid, Esmaeal Tamaddonfard |
Journal | Avicenna journal of phytomedicine
(Avicenna J Phytomed)
2015 Sep-Oct
Vol. 5
Issue 5
Pg. 469-78
ISSN: 2228-7930 [Print] Iran |
PMID | 26468467
(Publication Type: Journal Article)
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