A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy: clinical results with a median follow-up of 26 months.

Abstract

BACKGROUND:

A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy was performed. The first clinical results were reported with a median follow-up of 26 months.

PATIENTS AND METHODS:

Forty-six female breast cancer patients with positive hormone receptors and tumors ≤3 cm, pN0M0, completed the protocol treatment. After breast-conserving surgery and histological confirmation of negative surgical margins and pN0, brachytherapy applicators were implanted either postoperatively (n = 45) or intraoperatively (n = 1). High-dose-rate brachytherapy of 36 Gy/6 fractions was delivered. All clinical data were prospectively collected using case report forms and the Common Terminology Criteria for Adverse Events ver.3.0.

RESULTS:

At the median follow-up of 26 months, no breast cancer recurrence of any type was observed. Sequelae ≥G2 were dermatitis (G2, 7 %), fibrosis (G2, 11 %; G3, 4 %), fracture (G2, 2 %), pain (G2, 7 %; G3, 2 %), and soft tissue necrosis (G2, 6 %). Cosmetic outcomes evaluated by excellent/good scores were 100 % at pre-therapy (n = 46), 94 % at 12 months (n = 46), and 81 % at 24 months (n = 36), respectively.

CONCLUSIONS:

Disease control and sequelae were satisfactory due to the strict eligibility and protocol-defined treatment parameters. The cosmetic outcomes were comparable to those of previous Japanese breast-conserving therapy series.

• Authors: Takayuki Nose, Yuki Otani, Shuuji Asahi, Iwao Tsukiyama, Takushi Dokiya, Toshiaki Saeki, Ichirou Fukuda, Hiroshi Sekine, Naoto Shikama, Yu Kumazaki, Takao Takahashi, Ken Yoshida, Tadayuki Kotsuma, Norikazu Masuda, Eisaku Yoden, Kazutaka Nakashima, Taisei Matsumura, Shino Nakagawa, Seiji Tachiiri, Yoshio Moriguchi, Jun Itami, Masahiko Oguchi
• Journal: Breast cancer (Tokyo, Japan) (Breast Cancer) Vol. 23 Issue 6 Pg. 861-868 (Nov 2016) ISSN: 1880-4233 [Electronic] Japan
• PMID: 26467037 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Topics

• Adult
• Aged
• Asian People
• Brachytherapy (adverse effects, methods)
• Breast Neoplasms (pathology, radiotherapy, surgery)
• Dose Fractionation, Radiation
• Feasibility Studies
• Female
• Follow-Up Studies
• Humans
• Mastectomy, Segmental
• Middle Aged
• Radiotherapy Dosage
• Treatment Outcome