[Improved IgG Antibody Diagnostics of Feather Duvet Lung by an Antibody Screening Test].

Abstract

The underdiagnosed feather duvet lung, an extrinsic allergic alveolitis (hypersensitivity pneumonitis) caused by duck and goose feathers, can be more frequently diagnosed, if duck and goose feather antibodies are included in the panel of the routinely applied IgG antibody screening test. This does not necessarily require extending the screening test to include duck and goose feather antigens. By analysing 100 sera with duck and goose antibodies we found that the commonly used pigeon and budgerigar antibodies can also screen for feather duvet antibodies. All examined sera lacking pigeon and budgerigar antibodies also lacked clear-cut duck and goose feather antibodies. The examined sera with strong pigeon or budgerigar antibodies always also contained feather duvet antibodies. However, sera with medium or low concentrated pigeon or budgerigar antibodies are not always associated with feather duvet antibodies. In the light of these observations, we find that 71% of the duck and goose antibody analyses would be dispensable without essential loss of quality, if the results of screening for pigeon and budgerigar antibodies were incorporated into the procedure of a step-by- step diagnostics.

• Authors: J Sennekamp, E Lehmann
• Journal: Pneumologie (Stuttgart, Germany) (Pneumologie) Vol. 69 Issue 11 Pg. 638-44 (Nov 2015) ISSN: 1438-8790 [Electronic] Germany
• Vernacular Title: Optimierte IgG-Antikörperdiagnostik der Bettfedern-Alveolitis mittels EAA-Suchtest.
• PMID: 26458127 (Publication Type: Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Autoantibodies
• Immunoglobulin G

Topics

• Adolescent
• Adult
• Animals
• Autoantibodies (immunology)
• Bird Fancier's Lung (diagnosis, immunology)
• Ducks
• Feathers (immunology)
• Female
• Geese
• Humans
• Immunoassay (methods)
• Immunoglobulin G (immunology)
• Male
• Mass Screening (methods)
• Middle Aged
• Reproducibility of Results
• Sensitivity and Specificity
• Young Adult