Abstract |
Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a specific imaging probe. The purpose of the present study was to evaluate the feasibility of using (99m)Tc-HYNIC-βAla-Bombesin(7-14)as an imaging probe for Capan-1 pancreatic adenocarcinoma. Xenographic pancreatic tumor was developed in nude mice and characterized by histopathological analysis. Biodistribution studies and scintigraphic images were carried out in tumor-bearing nude mice. The two methods showed higher uptake by pancreatic tumor when compared to muscle (used as control), and the tumor-to-muscle ratio indicated that (99m)Tc-HYNIC-βAla-Bombesin (7-14)uptake was four-fold higher in tumor cells than in other tissues. Scintigraphic images also showed a clear signal at the tumor site. The present data indicate that (99m)Tc-HYNIC-βAla-Bombesin (7-14) may be useful for the detection of pancreatic adenocarcinoma.
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Authors | F N Carlesso, L L Fuscaldi, R S Araújo, C S Teixeira, M C Oliveira, S O A Fernandes, G D Cassali, D C Reis, A L B Barros, V N Cardoso |
Journal | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
(Braz J Med Biol Res)
Vol. 48
Issue 10
Pg. 923-8
(Oct 2015)
ISSN: 1414-431X [Electronic] Brazil |
PMID | 26445336
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organotechnetium Compounds
- Peptide Fragments
- technetium 99m HYNIC-beta-Ala-bombesin(7-14)
- Gastrin-Releasing Peptide
- Bombesin
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Topics |
- Adenocarcinoma
(diagnostic imaging, pathology)
- Animals
- Bombesin
(analogs & derivatives, pharmacokinetics)
- Cell Line, Tumor
- Gastrin-Releasing Peptide
(analogs & derivatives)
- Heterografts
(diagnostic imaging, pathology)
- Humans
- Male
- Mice, Nude
- Muscles
(diagnostic imaging)
- Organotechnetium Compounds
(pharmacokinetics)
- Pancreatic Neoplasms
(diagnostic imaging, pathology)
- Peptide Fragments
(pharmacokinetics)
- Radionuclide Imaging
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