Abstract | BACKGROUND:
Non-alcoholic fatty liver disease ( NAFLD) is a common liver disease that is strongly associated with obesity and dysregulation of insulin in the liver. However, currently no pharmacological agents have been established for the treatment of NAFLD. In this regard, we sought to evaluate the anti- NAFLD effects of Aralia elata (Miq) Seem (AE) extract and its ability to inhibit hepatic lipid accumulation and modulate cellular signaling in a high fat diet (HFD)-induced obese mouse model. METHODS: RESULTS: In the present study, AE extract was shown to reduce hepatic lipid accumulation and significantly downregulate the level of lipogenic genes and upregulate the expression of lipolysis genes in HepG2 cells. And also, AE extract significantly increased the glucose consumption, indicating that AE extract improved insulin resistance. Subsequently, we confirmed the inhibitory activity of AE extract on NAFLD, in vivo. Treatment with AE extract significantly decreased body weight and the fasting glucose level, alleviated hyperinsulinism and hyperlipidemia, and reduced glucose levels, as determined by OGTT. Additionally, AE extract decreased PI3K and Akt activity. CONCLUSIONS: Our results suggest that treatment with AE extract ameliorated NAFLD by inhibiting insulin resistance through activation of the Akt/GLUT4 pathway.
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Authors | Kyung-A Hwang, Yu-Jin Hwang, Ga Ram Kim, Jeong-Sook Choe |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 15
Pg. 347
(Oct 05 2015)
ISSN: 1472-6882 [Electronic] England |
PMID | 26438035
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Insulin
- PPAR alpha
- Plant Extracts
- Sterol Regulatory Element Binding Protein 1
- Carnitine O-Palmitoyltransferase
- Phosphatidylinositol 3-Kinases
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Topics |
- Animals
- Aralia
(chemistry)
- Carnitine O-Palmitoyltransferase
(genetics, metabolism)
- Diet, High-Fat
(adverse effects)
- Humans
- Insulin
(metabolism)
- Liver
(drug effects, metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Non-alcoholic Fatty Liver Disease
(drug therapy, enzymology, genetics, metabolism)
- PPAR alpha
(genetics, metabolism)
- Phosphatidylinositol 3-Kinases
(genetics, metabolism)
- Plant Extracts
(administration & dosage)
- Sterol Regulatory Element Binding Protein 1
(genetics, metabolism)
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