Regulation of lipid disorders by ethanol extracts from Zingiber zerumbet in high-fat diet-induced rats.

Abstract

The aim of this study was to investigate the antihyperlipidaemic effects of the ethanol extract of Zingiber zerumbet (L) Smith (EEZZ). After being fed a high-fat diet (HFD) for 2weeks, rats were dosed orally with EEZZ (100, 200 or 300mg/kg) or fenofibrate (100mg/kg) once daily for 8weeks. EEZZ (300mg/kg/day) produced effects similar to fenofibrate in reducing body weight gain, visceral fat-pad weights and plasma lipid levels. EEZZ caused reductions in hepatic triglyceride and cholesterol content, and lowered hepatic lipid droplet accumulation and the size of epididymal adipocytes. HFD-induced reductions in the hepatic proteins of peroxisome proliferator-activated receptor (PPAR) α, acyl-CoA oxidase (ACO) and cytochrome P450 isoform 4A1 (CYP4A1) were reversed by EEZZ. These results suggest that EEZZ reduced the accumulation of visceral fat and improved hyperlipidaemia in HFD-fed rats by increasing fatty acid oxidation, an effect which is likely to be mediated via up-regulation of hepatic PPARα.

• Authors: Chia Ju Chang, Thing-Fong Tzeng, Shorong-Shii Liou, Yuan-Shiun Chang, I-Min Liu
• Journal: Food chemistry (Food Chem) Vol. 132 Issue 1 Pg. 460-7 (May 01 2012) ISSN: 1873-7072 [Electronic] England
• PMID: 26434316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Hypolipidemic Agents
• Plant Extracts
• Plant Proteins
• Ethanol

Topics

• Animals
• Diet, High-Fat (adverse effects)
• Ethanol (metabolism)
• Zingiber officinale
• Hyperlipidemias (chemically induced, drug therapy)
• Hypolipidemic Agents (metabolism)
• Lipid Metabolism (drug effects)
• Male
• Plant Extracts (chemistry)
• Plant Proteins (chemistry)
• Rats