Abstract | PURPOSE: METHODS: Rabbits were subjected to trabeculectomy or Ex-PRESS tube shunt surgery and observed for up to 3 months. Intraocular pressure (IOP) was measured using a rebound tonometer. The MCP-1 level was measured by enzyme-linked immunosorbent assay (ELISA). Bleb morphology was evaluated using photos and anterior-segment optical coherence tomography (OCT). RESULTS: There were no differences in bleb appearance or IOP at any time between the groups. Bleb wall density in the anterior-segment OCT image was significantly lower 1 week after surgery in the Ex-PRESS group than the trabeculectomy group. The MCP-1 level in control eyes was 304.1 ± 45.2 pg/mL. In the trabeculectomy group, the mean aqueous MCP-1 level was 1444.9, 1914.3, 1899.8, 516.4, 398.3, 427.3, 609.5, 1612.7, 386.2, and 167.9 pg/mL at 3, 6, and 12 h, and 1, 2, 5, 7, 14, 30, and 90 days after surgery, respectively. In the Ex-PRESS group, the corresponding values were 1744.0, 1372.0, 932.5, 711.7, 396.1, 487.3, 799.5, 1327.9, 293.6, and 184.0 pg/mL. There were no significant differences in the aqueous MCP-1 level between the groups at any time point. CONCLUSION: The postoperative changes were similar in the Ex-PRESS and trabeculectomy groups, except for bleb wall density in the anterior-segment OCT image. The postoperative aqueous MCP-1 level had bimodal peaks in both groups.
|
Authors | Kohei Shobayashi, Toshihiro Inoue, Motofumi Kawai, Keiichiro Iwao, Saori Ohira, Sachi Kojima, Utako Kuroda, Kei-Ichi Nakashima, Hidenobu Tanihara |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 10
Pg. e0139751
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26427058
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- Chemokine CCL2
- MCP1 protein, rabbit
|
Topics |
- Animals
- Anterior Eye Segment
(metabolism, pathology, surgery)
- Biomarkers
(metabolism)
- Blister
(metabolism, pathology, surgery)
- Chemokine CCL2
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Glaucoma
(metabolism, pathology, surgery)
- Glaucoma Drainage Implants
- Image Processing, Computer-Assisted
- Immunoenzyme Techniques
- Ophthalmologic Surgical Procedures
- Postoperative Period
- Rabbits
- Trabeculectomy
(methods)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|