Abstract | BACKGROUND:
Iron is an essential micronutrient required by all living organisms including malaria parasites (Plasmodium spp.) for many biochemical reactions, especially growth and multiplication processes. Therefore, malaria parasite needs to take up the iron from outside or/and inside the parasitized red blood cells (PRBC). Iron chelators are widely used for the treatment of thalassaemia-related iron overload and also inhibit parasite growth at levels that are non-toxic to mammalian cells. METHODS: RESULTS: The IC50 values of DFO, GTE, CM1, DFX and DFP against P. falciparum were 14.09, 21.11, 35.14, 44.71 and 58.25 µM, respectively. Importantly, CM1 was more effective in reducing LIP levels in the P. falciparum culture than DFP (p < 0.05). CONCLUSIONS: CM1 and GTE exhibit anti-malarial activity. They could interfere with uptake of exogenous iron or deplete the intracellular labile iron pool in malaria parasites, leading to inhibition of their growth.
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Authors | Phitsinee Thipubon, Chairat Uthaipibull, Sumalee Kamchonwongpaisan, Wachiraporn Tipsuwan, Somdet Srichairatanakool |
Journal | Malaria journal
(Malar J)
Vol. 14
Pg. 382
(Sep 30 2015)
ISSN: 1475-2875 [Electronic] England |
PMID | 26424148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Iron Chelating Agents
- Plant Extracts
- Pyridones
- Tea
- Iron
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Topics |
- Antimalarials
(pharmacology)
- Erythrocytes
(chemistry, parasitology)
- Humans
- Iron
(analysis)
- Iron Chelating Agents
(pharmacology)
- Plant Extracts
(pharmacology)
- Plasmodium falciparum
(drug effects)
- Pyridones
(pharmacology)
- Tea
(chemistry)
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