TREATMENT OF PERSISTENTLY OPEN MACULAR HOLES WITH HEAVY SILICONE OIL (DENSIRON 68) VERSUS C2F6. A PROSPECTIVE RANDOMIZED STUDY.

Abstract

PURPOSE:

To compare the efficacy of a mixture of silicone oil and perfluorohexyloctane (Densiron 68) with C2F6 gas endotamponade in the retreatment of persistently open full-thickness macular holes.

METHODS:

In this prospective randomized study, 21 consecutive patients who were unsuccessfully operated on for large idiopathic full-thickness macular hole were randomly assigned to undergo a second vitrectomy with 20% perfluoroethane gas (C2F6, Group A) or with Densiron 68 tamponade (Group B).

PRIMARY OUTCOMES:

Endpoint (12 months) full-thickness macular hole closure rate by spectral domain optical coherence tomography and logMAR corrected distance visual acuity.

SECONDARY OUTCOMES:

postoperative adverse events.

RESULTS:

The mean diameter of macular holes before the second pars plana vitrectomy was 680.3 ± 120.8 μm and 740.5 ± 105.3 μm in Groups A and B, respectively (P = 0.237); mean preoperative corrected distance visual acuity was 0.96 ± 0.36 logMAR and 1.12 ± 0.35 logMAR, respectively (P = 0.315). Endpoint full-thickness macular hole closure was obtained in 30% of patients (3/10) in Group A and in 82% (9/11) in Group B (P = 0.030). Corrected distance visual acuities were, respectively, 0.80 ± 0.25 logMAR and 0.55 ± 0.20 logMAR, with significant intergroup difference (P = 0.019); corrected distance visual acuity increased in Group B only (P = 0.003). No differences in complications were found.

CONCLUSION:

The results indicate that Densiron 68 tamponade could be a useful, safe, and more efficacious method than gas tamponade to retreat persisting macular holes.

• Authors: Salvatore Cillino, Giovanni Cillino, Lucia Lee Ferraro, Alessandra Casuccio
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 36 Issue 4 Pg. 688-94 (Apr 2016) ISSN: 1539-2864 [Electronic] United States
• PMID: 26418444 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Fluorocarbons
• Silicone Oils
• densiron-68
• perfluoroethane

Topics

• Aged
• Aged, 80 and over
• Endotamponade
• Female
• Fluorocarbons (administration & dosage)
• Humans
• Male
• Middle Aged
• Prospective Studies
• Reoperation
• Retinal Perforations (diagnosis, physiopathology, therapy)
• Silicone Oils (administration & dosage)
• Tomography, Optical Coherence
• Visual Acuity (physiology)
• Vitrectomy