Clinical translation of a high-performance neural prosthesis.

Abstract

Neural prostheses have the potential to improve the quality of life of individuals with paralysis by directly mapping neural activity to limb- and computer-control signals. We translated a neural prosthetic system previously developed in animal model studies for use by two individuals with amyotrophic lateral sclerosis who had intracortical microelectrode arrays placed in motor cortex. Measured more than 1 year after implant, the neural cursor-control system showed the highest published performance achieved by a person to date, more than double that of previous pilot clinical trial participants.

• Authors: Vikash Gilja, Chethan Pandarinath, Christine H Blabe, Paul Nuyujukian, John D Simeral, Anish A Sarma, Brittany L Sorice, János A Perge, Beata Jarosiewicz, Leigh R Hochberg, Krishna V Shenoy, Jaimie M Henderson
• Journal: Nature medicine (Nat Med) Vol. 21 Issue 10 Pg. 1142-5 (Oct 2015) ISSN: 1546-170X [Electronic] United States
• PMID: 26413781 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Humans
• Microelectrodes
• Neural Prostheses
• Paralysis (therapy)
• Quality of Life
• Translational Research, Biomedical