Abstract | OBJECTIVES: The aim of this study was to determine the effect of remote ischemic preconditioning (RIPC) on markers of cardiac ischemia and response to oxidative stress in patients undergoing coronary artery bypass grafting (CABG) surgery. DESIGN: A prospective, randomized, and blinded study. SETTING: A single-center university hospital. PARTICIPANTS: This study included patients who underwent isolated CABG surgery with cardiopulmonary bypass who were selected carefully to prevent confounding with factors known to affect markers of ischemia-reperfusion and response to oxidative stress. INTERVENTIONS: The authors randomly assigned patients to RIPC to the left lower extremity using a blood pressure cuff (study group) or a cuff that was applied but not inflated or deflated (control group). MEASUREMENTS AND MAIN RESULTS: At 6 hours after CABG surgery, high-sensitivity cardiac troponin T levels were significantly lower in the study group than in the control group. Levels of superoxide dismutase, an antioxidant enzyme, were significantly greater 15 minutes after release of the cross-clamp in the study group, whereas malondialdehyde levels were lower (not significantly) at 1 and 15 minutes after release of the cross-clamp. Hemodynamic parameters were not significantly different at any time point during the study. CONCLUSIONS:
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Authors | Funda Yildirim, Ihsan Iskesen, Adnan Taner Kurdal, Tulun Ozturk, Fatma Taneli, Ceyhun Gozukara, Alper Ozbakkaloglu |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 30
Issue 1
Pg. 134-40
(Jan 2016)
ISSN: 1532-8422 [Electronic] United States |
PMID | 26411813
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Antioxidants
(metabolism)
- Cardiac Surgical Procedures
(methods)
- Female
- Humans
- Ischemic Preconditioning
(methods)
- Male
- Middle Aged
- Myocardial Infarction
(blood, diagnosis, therapy)
- Oxidative Stress
(physiology)
- Prospective Studies
- Single-Blind Method
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