Serum Amyloid A-Positive Hepatocellular Neoplasm: A New Type of Tumor Arising in Patients with Advanced Alcoholic Disease.

Abstract

This chapter reviews a new type of hepatocellular neoplasm, serum amyloid A-positive hepatocellular neoplasm (SAA-HN), which arises in patients with advanced alcoholic liver disease such as cirrhosis. SAA-HNs share histological and immunohistochemical features with inflammatory hepatocellular adenoma, for example, a strong immunoreactivity for SAA. Clinicopathological features and issues regarding SAA-HN are reviewed with emphasis regarding its potential to develop into hepatocellular carcinoma.

• Authors: Motoko Sasaki, Yasuni Nakanuma
• Journal: Digestive diseases (Basel, Switzerland) (Dig Dis) Vol. 33 Issue 5 Pg. 648-54 (Sep 2015) ISSN: 1421-9875 [Electronic] Switzerland
• PMID: 26398230 (Publication Type: Journal Article, Review)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• Serum Amyloid A Protein

Topics

• Adenoma, Liver Cell (diagnosis, etiology, physiopathology)
• Carcinoma, Hepatocellular (diagnosis, etiology, physiopathology)
• Humans
• Liver Cirrhosis (diagnosis, etiology, physiopathology)
• Liver Diseases, Alcoholic (complications, diagnosis, physiopathology)
• Liver Neoplasms (diagnosis, etiology, physiopathology)
• Serum Amyloid A Protein (genetics, metabolism)