Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection.

Abstract

We used bone marrow/liver/thymus (BLT) humanized mice to establish the effect of semen on vaginal HIV infection and on the efficacy of topically applied maraviroc. Our results demonstrate that vaginal transmission of cell-free HIV occurs efficiently in the presence of semen and that topically applied maraviroc efficiently prevents HIV transmission in the presence of semen. We also show that semen has no significant effect on the transmission of transmitted/founder viruses or cell-associated viruses.

• Authors: Olivia D Council, Michael D Swanson, Rae Ann Spagnuolo, Angela Wahl, J Victor Garcia
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 12 Pg. 7847-51 (Dec 2015) ISSN: 1098-6596 [Electronic] United States
• PMID: 26392489 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• Anti-HIV Agents
• Cyclohexanes
• Triazoles
• Maraviroc

Topics

• Administration, Intravaginal
• Animals
• Anti-HIV Agents (pharmacology)
• CD4-Positive T-Lymphocytes (drug effects, immunology, virology)
• Cyclohexanes (pharmacology)
• Disease Models, Animal
• Female
• HIV Infections (immunology, prevention & control, transmission, virology)
• HIV-1 (drug effects, physiology)
• Humans
• Male
• Maraviroc
• Mice
• Mice, Transgenic
• Semen (drug effects, virology)
• Triazoles (pharmacology)
• Vagina (drug effects, immunology, virology)
• Viral Load (drug effects)