The emerging roles of F-box proteins in pancreatic tumorigenesis.

Abstract

The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.

• Authors: Hua Wang, Anirban Maitra, Huamin Wang
• Journal: Seminars in cancer biology (Semin Cancer Biol) Vol. 36 Pg. 88-94 (Feb 2016) ISSN: 1096-3650 [Electronic] England
• PMID: 26384530 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015. Published by Elsevier Ltd.

Chemical References

• Cell Cycle Proteins
• F-Box Proteins
• F-Box-WD Repeat-Containing Protein 7
• FBXW7 protein, human
• FBXW8 protein, human
• Multiprotein Complexes
• Proteome
• Ubiquitins
• Ubiquitin-Protein Ligases

Topics

• Animals
• Cell Cycle Proteins (genetics, metabolism)
• Cell Transformation, Neoplastic (genetics, metabolism)
• F-Box Proteins (genetics, metabolism)
• F-Box-WD Repeat-Containing Protein 7
• Gene Expression Regulation, Neoplastic
• Humans
• Insulin-Secreting Cells (metabolism, pathology)
• Multiprotein Complexes (metabolism)
• Pancreatic Neoplasms (etiology, metabolism, pathology)
• Protein Binding
• Proteome (metabolism)
• Signal Transduction
• Ubiquitin-Protein Ligases (genetics, metabolism)
• Ubiquitins (metabolism)