Abstract | OBJECTIVE: The objective of this study was to identify the differences in medication effect according to pain characteristics in spinal cord-injured patients. METHODS: This study is a prospective, randomized, crossover study. Fifty-five patients and 66 locations of neuropathic pain were included. Pain was classified into four spontaneous characteristics and three evoked pain characteristics. Oxcarbazepine (Na channel blocker) and pregabalin ( calcium channel α2-δ ligand medication) were tried. Patients were divided into two groups: evoked pain present and evoked pain absent. Overall average visual analog scale was obtained. RESULTS: CONCLUSIONS: In summary, the phenotype of neuropathic pain was associated with the efficacy of different pharmacologic treatments. Symptom-based treatment, therefore, can lead to more efficient analgesia.
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Authors | Kyunghoon Min, Yoongul Oh, Sang-Hyuk Lee, Ju Seok Ryu |
Journal | American journal of physical medicine & rehabilitation
(Am J Phys Med Rehabil)
Vol. 95
Issue 5
Pg. 330-8
(May 2016)
ISSN: 1537-7385 [Electronic] United States |
PMID | 26368836
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channel Blockers
- Voltage-Gated Sodium Channel Blockers
- Carbamazepine
- Pregabalin
- Oxcarbazepine
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Topics |
- Calcium Channel Blockers
(therapeutic use)
- Carbamazepine
(analogs & derivatives, therapeutic use)
- Cross-Over Studies
- Evoked Potentials
(physiology)
- Female
- Humans
- Male
- Middle Aged
- Neuralgia
(drug therapy, physiopathology)
- Oxcarbazepine
- Pregabalin
(therapeutic use)
- Prospective Studies
- Spinal Cord Injuries
(physiopathology)
- Visual Analog Scale
- Voltage-Gated Sodium Channel Blockers
(therapeutic use)
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