Abstract | OBJECTIVES: METHODS: This meta-analysis was conducted between November 2014 and February 2015 in Shanghai Medical Instrumentation College, Shanghai, China. We collected all published available case-control data (N=12) identified through PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI) up to December 2014. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed- or random-effect model. RESULTS: Although subgroup analysis showed that alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals (OR=1.55, 95% CI=1.22-1.98, p=0.0003), our meta-analysis results did not confirm such association overall (OR=1.03, 95% CI=0.92-1.15, p=0.62). The lack of association was further confirmed by the non-superiority test (p less than 0.0001). CONCLUSION:
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Authors | Wenchao Yang, Zhenmin Zhu, Jin Wang, Wei Ye, Yong Ding |
Journal | Saudi medical journal
(Saudi Med J)
Vol. 36
Issue 9
Pg. 1039-45
(Sep 2015)
ISSN: 1658-3175 [Electronic] Saudi Arabia |
PMID | 26318459
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Epithelial Sodium Channels
- SCNN1A protein, human
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Topics |
- Epithelial Sodium Channels
(genetics)
- Essential Hypertension
- Humans
- Hypertension
(genetics)
- Polymorphism, Single Nucleotide
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