HLA Class II Differentiates Between Thyroid and Polyglandular Autoimmunity.

Abstract	The HLA class II genes are susceptibility genes for autoimmune endocrine diseases; however, scarce data are available pertaining to the determinants of genetic susceptibility to polyglandular autoimmunity (PGA). A total of 300 consecutive and unselected patients with either PGA or monoglandular autoimmune thyroid disease (AITD) and 100 healthy control subjects were genotyped for the HLA class II DRB1, -DQA1, and -DQB1 alleles. Compared to patients with AITD and controls, the HLA-DRB103 (pc =0.001), 04 (pc<0.001), -DQA103 (pc<0.001), and -DQB102 (pc =0.001) alleles were increased in patients with PGA. When dividing patients with Hashimoto's thyroiditis (HT) into those with PGA (PGA-HT) vs. those with HT as monoglandular disease, significant differences for the DRB103 (pc=0.001) and DQA103 (pc=0.001) alleles were observed. In contrast, the DQB102 allele was more prevalent in PGA patients with Graves' disease (PGA-GD) vs. those with monoglandular GD (pc=0.002). The HLA-DRB115 (pc =0.001), -DQA101 (pc =0.001), -DQB105 (pc =0.002) and -DQB1*06 (pc =0.002) alleles were significantly less present in PGA compared to monoglandular AITD and controls, thus indicating protective alleles. The HLA class II alleles differentiate between mono- and polyglandular autoimmunity in patients with autoimmune thyroid disease.
Authors	S Barkia Beradhi, B K Flesch, M P Hansen, N Matheis, G J Kahaly
Journal	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 48 Issue 4 Pg. 232-7 (Apr 2016) ISSN: 1439-4286 [Electronic] Germany
PMID	26317691 (Publication Type: Journal Article)
Copyright	© Georg Thieme Verlag KG Stuttgart · New York.
Chemical References	Histocompatibility Antigens Class II
Topics	Adolescent Adult Autoimmunity Child Child, Preschool Female Genetic Predisposition to Disease Graves Disease (genetics, immunology) Hashimoto Disease (genetics, immunology) Histocompatibility Antigens Class II (genetics, immunology) Humans Infant Male Middle Aged Thyroid Gland (immunology) Young Adult

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