Protocatechuic acid protects brain mitochondrial function in streptozotocin-induced diabetic rats.

Abstract

Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, has been shown to exert glycemic control and oxidative stress reduction in the heart. However, its effects on oxidative stress and mitochondrial function in the brain under diabetic condition have never been investigated. We found that PCA exerted glycemic control, attenuates brain mitochondrial dysfunction, and contributes to the prevention of brain oxidative stress in diabetic rats.

• Authors: Yoswaris Semaming, Jirapas Sripetchwandee, Piangkwan Sa-Nguanmoo, Hiranya Pintana, Patchareewan Pannangpetch, Nipon Chattipakorn, Siriporn C Chattipakorn
• Journal: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme (Appl Physiol Nutr Metab) Vol. 40 Issue 10 Pg. 1078-81 (Oct 2015) ISSN: 1715-5320 [Electronic] Canada
• PMID: 26316260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Hydroxybenzoates
• protocatechuic acid

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Brain (drug effects)
• Diabetes Mellitus, Experimental
• Disease Models, Animal
• Hydroxybenzoates (pharmacology)
• Male
• Mitochondria (drug effects)
• Rats
• Rats, Sprague-Dawley