Abstract | OBJECTIVES/HYPOTHESIS: STUDY DESIGN: Prospective, controlled clinical study. METHODS: Fifty-three patients with nasopharyngeal carcinoma (106 ears). Twenty-five patients (50 ears) received radiotherapy with intravenous methylprednisolone for 14 days, and another 28 patients (56 ears) received radiotherapy alone. Pure tone audiometry, distortion product otoacoustic emission (DPOAE), and auditory brainstem responses (ABR) results were reviewed before and 1 year after radiotherapy. RESULT: One year after radiotherapy, the air-and-bone conduction pure tone hearing thresholds increased, and the DPOAE levels decreased in the control group. There was no difference in the ABR wave I, III, and V latencies and the I to V interwave latencies before and 1 year after radiotherapy. The pure tone air conduction thresholds decreased, and the DPOAE levels increased in the treatment group compared with the control group. CONCLUSION:
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Authors | Junming Chen, Yuanxin Zhao, Xiaowei Zhou, Lingmei Tan, Zeying Ou, Youjun Yu, Yuejian Wang |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 126
Issue 1
Pg. 100-3
(Jan 2016)
ISSN: 1531-4995 [Electronic] United States |
PMID | 26309227
(Publication Type: Clinical Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The American Laryngological, Rhinological and Otological Society, Inc. |
Chemical References |
- Neuroprotective Agents
- Methylprednisolone
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Topics |
- Adult
- Audiometry, Pure-Tone
- Carcinoma
- Evoked Potentials, Auditory, Brain Stem
- Female
- Hair Cells, Auditory, Outer
(radiation effects)
- Hearing Loss, Sensorineural
(etiology, prevention & control)
- Humans
- Male
- Methylprednisolone
(therapeutic use)
- Middle Aged
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms
(radiotherapy)
- Neuroprotective Agents
(therapeutic use)
- Otoacoustic Emissions, Spontaneous
- Prospective Studies
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