Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.

Abstract

Antibody-drug conjugates have attracted a great amount of attention as a therapeutic strategy for diseases where targeting specific tissues and cells are critical components, such as in cancer therapy. Although promising, the number of approved ADC drugs is relatively limited. This emanates from the challenges associated with generating the conjugates and the complexities associated with the stability requirements for these conjugates during circulation and after reaching the target. Here, we provide a comprehensive overview of the design challenges facing the ADC field. These challenges also provide several unique research and development opportunities, which are also highlighted throughout the review.

• Authors: Mallory R Gordon, Mine Canakci, Longyu Li, Jiaming Zhuang, Barbara Osborne, S Thayumanavan
• Journal: Bioconjugate chemistry (Bioconjug Chem) Vol. 26 Issue 11 Pg. 2198-215 (Nov 18 2015) ISSN: 1520-4812 [Electronic] United States
• PMID: 26308881 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Immunoconjugates

Topics

• Animals
• Biocatalysis
• Chemistry Techniques, Synthetic (methods)
• Humans
• Immunoconjugates (chemistry)
• Models, Molecular
• Nanoparticles (chemistry)