The Ratio KL-6 to SLX in Serum for Prediction of the Occurrence of Drug-Induced Interstitial Lung Disease in Lung Cancer Patients with Idiopathic Interstitial Pneumonias Receiving Chemotherapy.

Abstract

We retrospectively evaluated whether the ratio KL-6 to SLX in serum (K/S ratio) before chemotherapy was a predictor for the occurrence of drug-induced interstitial lung disease (D-ILD) in lung cancer patients with idiopathic interstitial pneumonias (IIPs). D-ILD occurred in 8 of 20 IIPs-positive cases and in 14 of 100 IIPs-negative cases (40 vs. 14%, p = .015). In IIPs-positive cases, the high K/S ratio (>20) before first-line chemotherapy had a tendency to increase the risk of D-ILD (p = .085). Serum K/S ratio may be a useful predictor for the occurrence of D-ILD in lung cancer patients with IIPs.

• Authors: Kosuke Kashiwabara, Hiroshi Semba, Shinji Fujii, Shinsuke Tsumura, Ryota Aoki
• Journal: Cancer investigation (Cancer Invest) Vol. 33 Issue 10 Pg. 516-21 ( 2015) ISSN: 1532-4192 [Electronic] England
• PMID: 26305851 (Publication Type: Journal Article)

Chemical References

• MUC1 protein, human
• Mucin-1
• Endodeoxyribonucleases
• Endonucleases
• SLX1 protein, human

Topics

• Aged
• Endodeoxyribonucleases
• Endonucleases (blood, metabolism)
• Female
• Humans
• Idiopathic Interstitial Pneumonias (drug therapy)
• Lung Diseases, Interstitial (chemically induced)
• Male
• Mucin-1 (blood, metabolism)
• Retrospective Studies