Dissemination of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa in Romania.

Abstract

Fifteen carbapenemase-producing Enterobacteriaceae isolates and 12 carbapenemase-producing Pseudomonas aeruginosa isolates were recovered from patients hospitalized between August 2011 and March 2013 at the Hospital of Infectious Disease, Cluj-Napoca, Romania. One KPC-, nine NDM-1-, four OXA-48-, and one VIM-4-producing Enterobacteriaceae isolates along with 11 VIM-2-producing and one IMP-13-producing P. aeruginosa isolates were recovered from clinical samples. All carbapenemase genes were located on self-conjugative plasmids and were associated with other resistance determinants, including extended-spectrum β-lactamases and RmtC methylases.

• Authors: Laurent Dortet, Mirela Flonta, Yves-Marie Boudehen, Elodie Creton, Sandrine Bernabeu, Anaïs Vogel, Thierry Naas
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 11 Pg. 7100-3 (Nov 2015) ISSN: 1098-6596 [Electronic] United States
• PMID: 26303798 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• Anti-Bacterial Agents
• Bacterial Proteins
• beta-Lactamases
• carbapenemase

Topics

• Anti-Bacterial Agents (pharmacology)
• Bacterial Proteins (metabolism)
• Enterobacteriaceae (drug effects, enzymology)
• Plasmids (genetics)
• Pseudomonas aeruginosa (drug effects, enzymology)
• Romania
• beta-Lactamases (metabolism)