Comparing the Efficacy of 8 Weeks Treatment of Cipram® and its Generic Citalopram in Patients With Mixed Anxiety-Depressive Disorder.

Abstract

BACKGROUND:

Patients with mixed anxiety-depressive disorder (MADD) suffer both anxiety and depression. Antidepressants, especially, selective serotonin reuptake inhibitors are among agents of choice for treating this condition.

OBJECTIVES:

This study compared the efficacy of Cipram® with its generic, citalopram.

PATIENTS AND METHODS:

Forty adult outpatients (between 18 to 55 years of age) with a diagnosis of MADD who met the trial criteria, entered this double-blind, randomized study. Subjects were assigned to receive either generic citalopram or Cipram® for 8 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were utilized to assess depression and anxiety at baseline, weeks 4 and 8 of the study. Statistical analysis was performed using SPSS 14.0.

RESULTS:

Twenty patients received citalopram (mean dosages of 22 mg/day during the first 4 weeks and 33 mg/day during weeks 4 to 8) and 20 received Cipram® (mean dosages of 22 mg/day during the first 4 weeks and 29 mg/day during weeks 4 to 8). Both treatments were noted to be effective in improving the symptoms of MADD at weeks 4 and 8. The mean differences of HAM-D and HAM-A between Citalopram and Cipram® groups were significantly different at the end of week 4 (HAM-D: P = 0.038, HAM-A: P = 0.025), but not at the end of week 8 (HAM-D: P = 0.239, HAM-A: P = 0.204). Both medications were tolerated well by the patients.

CONCLUSIONS:

This study suggests that the efficacy of citalopram is similar to that of Cipram® in the treatment of MADD after 8 weeks. Meanwhile, Cipram® may reduce depression and anxiety quicker than its generic, citalopram.

• Authors: Hasan Khoonsari, Mohammad Bagher Oghazian, Mona Kargar, Mahdiyeh Moin, Hossein Khalili, Abbas Alimadadi, Hassan Torkamandi, Padideh Ghaeli
• Journal: Iranian journal of psychiatry and behavioral sciences (Iran J Psychiatry Behav Sci) Vol. 9 Issue 2 Pg. e230 (Jun 2015) ISSN: 1735-8639 [Print] Netherlands
• PMID: 26288644 (Publication Type: Journal Article)