A small-scale open-label study of the treatment of canine flea allergy dermatitis with fluralaner.

Abstract

BACKGROUND:

Fluralaner is an isoxazoline systemic insecticide and acaricide that provides persistent flea-killing activity on dogs for 12 weeks. European and US field studies have shown that fluralaner treatment alleviates the signs of flea allergy dermatitis (FAD) in client-owned dogs.

HYPOTHESIS/OBJECTIVE:

To assess the clinical response in FAD affected dogs over the 12-week period following a single oral fluralaner treatment.

ANIMALS:

Twenty client-owned dogs were diagnosed with FAD on the basis of compatible clinical signs and a positive response in flea antigen tests, using intradermal and or serological methods.

METHODS:

An open-label small-scale study with all dogs receiving a single oral fluralaner treatment. All enrolled dogs were diagnosed with FAD and then clinically monitored at 4-week intervals for 12 weeks. Twenty dogs completed the study.

RESULTS:

All dogs were flea-free at all post-treatment assessments except for one dog that had a single flea at the first post-enrollment assessment at 4 weeks. At the 4-week post-treatment assessment active FAD signs had resolved in all dogs; at 8 weeks post-treatment, two dogs showed mild signs. All clinical signs of FAD had resolved at the final assessment of 12 weeks after treatment.

CONCLUSIONS AND CLINICAL IMPORTANCE:

A single administration of fluralaner alleviated or resolved signs associated with FAD in all treated dogs over the recommended 12-week treatment period.

• Authors: Petr Fisara, Michael Shipstone, Andrew von Berky, Janet von Berky
• Journal: Veterinary dermatology (Vet Dermatol) Vol. 26 Issue 6 Pg. 417-20, e97-8 (Dec 2015) ISSN: 1365-3164 [Electronic] England
• PMID: 26271195 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 The Authors. Veterinary Dermatology published by John Wiley & Sons Ltd on behalf of Intervet Australia Pty Ltd.

Chemical References

• A1443 compound
• Insecticides
• Isoxazoles

Topics

• Administration, Oral
• Animals
• Dermatitis, Allergic Contact (drug therapy, veterinary)
• Dog Diseases (drug therapy, parasitology)
• Dogs
• Female
• Flea Infestations (immunology, veterinary)
• Insecticides (administration & dosage, therapeutic use)
• Isoxazoles (administration & dosage, therapeutic use)
• Male