The evolving role of dabigatran etexilate in clinical practice.

Abstract

INTRODUCTION:

Stroke and venous thromboembolism (VTE) affect millions of patients. The vitamin K antagonist, warfarin, has been the main oral anticoagulant used to treat these conditions despite many limitations associated with its use. Recently, multiple novel oral anticoagulants have been approved and are reshaping how patients with atrial fibrillation (AF) at risk of stroke and patients with VTE are treated. The direct thrombin inhibitor, dabigatran etexilate , is among these novel agents that have been developed to overcome limitations with warfarin.

AREAS COVERED:

In this article, authors describe the pharmacokinetic and pharmacodynamic properties of dabigatran etexilate and summarize the clinical evidence and controversy surrounding its use in the US, Canada and Europe.

EXPERT OPINION:

Dabigatran has demonstrated similar efficacy and safety to enoxaparin for VTE prevention in patients undergoing hip and knee arthroplasty, and to warfarin for the treatment of VTE. Dabigatran (110 mg) is noninferior and dabigatran (150 mg) is superior to warfarin for stroke prevention in patients with nonvalvular AF, with a lower rate of intracranial hemorrhage reported at both doses. Apixaban, rivaroxaban and edoxaban provide alternate anticoagulant options to dabigatran. While there are many similarities, there are also significant differences to consider in agent selection based on patient-specific characteristics.

• Authors: Erika Hellenbart, Beatrice Drambarean, James Lee, Edith A Nutescu
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 16 Issue 13 Pg. 2053-72 ( 2015) ISSN: 1744-7666 [Electronic] England
• PMID: 26245513 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antithrombins
• Enoxaparin
• Pyrazoles
• Pyridines
• Pyridones
• Thiazoles
• apixaban
• Rivaroxaban
• Dabigatran
• edoxaban

Topics

• Antithrombins (pharmacokinetics, therapeutic use)
• Arthroplasty, Replacement, Knee
• Atrial Fibrillation (drug therapy)
• Cardiovascular Diseases (drug therapy)
• Clinical Trials as Topic
• Dabigatran (pharmacokinetics, therapeutic use)
• Enoxaparin (therapeutic use)
• Humans
• Pyrazoles (therapeutic use)
• Pyridines (therapeutic use)
• Pyridones (therapeutic use)
• Rivaroxaban (therapeutic use)
• Stroke (prevention & control)
• Thiazoles (therapeutic use)
• Venous Thromboembolism (drug therapy)