Abstract | BACKGROUND AND AIMS: METHODS: We used baseline data from 3200 non-diabetic male participants in the Aragon Workers' Health Study. We conducted analysis to estimate age-adjusted odds ratios ( ORs) across tertiles of HbA1c and insulin. Fasting glucose and Homeostatic model assessment - Insulin Resistance were used as reference. Here we report the uppermost-to-lowest tertile ORs (95%CI). RESULTS: Mean age (SD) was 48.5 (8.8) years and 23% of participants had metabolic syndrome. The ORs for metabolic syndrome criteria tended to be higher across HbA1c than across glucose, except for high blood pressure. Insulin was associated with the criteria more strongly than HbA1c and similarly to Homeostatic model assessment - Insulin Resistance (HOMA-IR). For metabolic syndrome, the OR of HbA1c was 2.68, of insulin, 11.36, of glucose, 7.03, and of HOMA-IR, 14.40. For the clustering of 2 or more non-glycemic criteria, the OR of HbA1c was 2.10, of insulin, 8.94, of glucose, 1.73, and of HOMA-IR, 7.83. All ORs were statistically significant. The areas under the receiver operating characteristics curves for metabolic syndrome were 0.670 (across HbA1c values) and 0.770 (across insulin values), and, for insulin resistance, 0.647 (HbA1c) and 0.995 ( insulin). Among non- metabolic syndrome patients, a small insulin elevation identified risk factor clustering. CONCLUSIONS:
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Authors | Gabriela Saravia, Fernando Civeira, Yamilee Hurtado-Roca, Eva Andres, Montserrat Leon, Miguel Pocovi, Jose Ordovas, Eliseo Guallar, Antonio Fernandez-Ortiz, Jose Antonio Casasnovas, Martin Laclaustra |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 8
Pg. e0132244
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26241903
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- Triglycerides
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Topics |
- Adult
- Antihypertensive Agents
(therapeutic use)
- Cohort Studies
- Comorbidity
- Cross-Sectional Studies
- Diabetes Mellitus
(blood, drug therapy, epidemiology)
- Fasting
(blood)
- Glycated Hemoglobin
(analysis)
- Homeostasis
- Humans
- Hypertension
(blood, drug therapy, epidemiology)
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(blood)
- Insulin Resistance
- Male
- Metabolic Syndrome
(blood, epidemiology)
- Middle Aged
- Models, Biological
- Occupational Health
- Odds Ratio
- Risk Factors
- Spain
(epidemiology)
- Triglycerides
(blood)
- Waist Circumference
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