Abstract |
Farnesiferol C is a natural compound with various anti- cancer properties that belongs to the class of sesquiterpene coumarins. However, the low bioavailability of farnesiferol C limits its therapeutic potential. Here, we overcame this problem utilizing dendrosome nano-particles and evaluated the anti- cancer effect of dendrosomal farnesiferol C (DFC) on the AGS gastric cancer cell line. The 3-(4,5-dimethyl-thiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and reverse transcriptase-polymerase chain reaction (RT-PCR) were respectively used to detect the anti-proliferative properties of DFC and expression ratio of Bax/Bcl-2 as a hallmark of apoptosis. Compared to the void farnesiferol C (FC), our data showed that DFC significantly suppresses the proliferation of AGS cells in a time- and dose-dependent manner (P<0.01). Also, DFC meaningfully increased the expression ratio of Bax/Bcl-2 in AGS cells (P<0.01). The findings demonstrate that our nano-based formulation of farnesiferol C could be considered as a potential therapeutic agent in cancer targeting.
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Authors | Zohreh Aas, Esmaeil Babaei, Mohammad Ali Hosseinpour Feizi, Gholamreza Dehghan |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 16
Issue 13
Pg. 5325-9
( 2015)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 26225673
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Coumarins
- Dendrimers
- RNA, Messenger
- farnesiferol C
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Apoptosis
(drug effects)
- Cell Proliferation
(drug effects)
- Coumarins
(pharmacology)
- Dendrimers
(chemistry)
- Drug Delivery Systems
- Humans
- Nanoparticles
(administration & dosage)
- RNA, Messenger
(genetics)
- Real-Time Polymerase Chain Reaction
- Receptors, Vascular Endothelial Growth Factor
(antagonists & inhibitors)
- Reverse Transcriptase Polymerase Chain Reaction
- Stomach Neoplasms
(drug therapy, genetics, pathology)
- Tumor Cells, Cultured
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