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Anti-proliferative and Apoptotic Effects of Dendrosomal Farnesiferol C on Gastric Cancer Cells.

Abstract
Farnesiferol C is a natural compound with various anti-cancer properties that belongs to the class of sesquiterpene coumarins. However, the low bioavailability of farnesiferol C limits its therapeutic potential. Here, we overcame this problem utilizing dendrosome nano-particles and evaluated the anti-cancer effect of dendrosomal farnesiferol C (DFC) on the AGS gastric cancer cell line. The 3-(4,5-dimethyl-thiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and reverse transcriptase-polymerase chain reaction (RT-PCR) were respectively used to detect the anti-proliferative properties of DFC and expression ratio of Bax/Bcl-2 as a hallmark of apoptosis. Compared to the void farnesiferol C (FC), our data showed that DFC significantly suppresses the proliferation of AGS cells in a time- and dose-dependent manner (P<0.01). Also, DFC meaningfully increased the expression ratio of Bax/Bcl-2 in AGS cells (P<0.01). The findings demonstrate that our nano-based formulation of farnesiferol C could be considered as a potential therapeutic agent in cancer targeting.
AuthorsZohreh Aas, Esmaeil Babaei, Mohammad Ali Hosseinpour Feizi, Gholamreza Dehghan
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 13 Pg. 5325-9 ( 2015) ISSN: 2476-762X [Electronic] Thailand
PMID26225673 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Coumarins
  • Dendrimers
  • RNA, Messenger
  • farnesiferol C
  • Receptors, Vascular Endothelial Growth Factor
Topics
  • Apoptosis (drug effects)
  • Cell Proliferation (drug effects)
  • Coumarins (pharmacology)
  • Dendrimers (chemistry)
  • Drug Delivery Systems
  • Humans
  • Nanoparticles (administration & dosage)
  • RNA, Messenger (genetics)
  • Real-Time Polymerase Chain Reaction
  • Receptors, Vascular Endothelial Growth Factor (antagonists & inhibitors)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stomach Neoplasms (drug therapy, genetics, pathology)
  • Tumor Cells, Cultured

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