Mammary-Derived Growth Inhibitor Targeting Peptide-Modified PEG-PLA Nanoparticles for Enhanced Targeted Glioblastoma Therapy.

Abstract

Targeting delivery of chemotherapeutics to neovasculature represents a promising means for tumor therapy since angiogenesis has been a featured hallmark of glioblastma. However, anti-angiogenic therapy would induce the occurrence of metastatic tumor and even neoplasm recurrence. Simultaneous targeting of tumor cells and neovasculature perfectly overcome such defects and has been proven to be an efficacious strategy for suppressing tumor growth. In the present study, a tumor homing peptide CooP selective binding to mammary-derived growth inhibitor that overexpressed in glioma cells and blood vessel endothelial cells was decorated on the surface of paclitaxel-loading PEG-PLA nanoparticles (NP-PTX) to obtain the dual targeting nanovector CooP-NP-PTX. In vitro antiproliferation study showed that HUVEC cells and U87MG cells were much more sensitive to CooP-NP-PTX than NP-PTX. In vivo imaging demonstrated that CooP-NP accumulated more selectively and penetrated deeper into the tumor site. In addition, the glioma-bearing mice treated with CooP-NP-PTX achieved the longest survival time compared to NP-PTX and Taxol. The findings observed above indicated that CooP peptide-functionalized anti-neoplastic agent-loaded nanoparticles might possess promising potential for glioblastoma therapy.

• Authors: Xingye Feng, Xiaoling Gao, Ting Kang, Di Jiang, Jianhui Yao, Yixian Jing, Qingxiang Song, Xinguo Jiang, Jianying Liang, Jun Chen
• Journal: Bioconjugate chemistry (Bioconjug Chem) Vol. 26 Issue 8 Pg. 1850-61 (Aug 19 2015) ISSN: 1520-4812 [Electronic] United States
• PMID: 26222392 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Fabp3 protein, mouse
• Fatty Acid Binding Protein 3
• Fatty Acid-Binding Proteins
• Peptide Fragments
• monomethoxypolyethyleneglycol-polylactide block copolymer
• Polyethylene Glycols
• Paclitaxel

Topics

• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage, pharmacology)
• Apoptosis (drug effects)
• Cell Proliferation (drug effects)
• Drug Delivery Systems
• Fatty Acid Binding Protein 3
• Fatty Acid-Binding Proteins (metabolism)
• Glioblastoma (drug therapy, metabolism, pathology)
• Human Umbilical Vein Endothelial Cells (metabolism)
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Nanoparticles (administration & dosage, chemistry)
• Paclitaxel (administration & dosage, pharmacology)
• Peptide Fragments (chemistry, metabolism)
• Polyethylene Glycols (chemistry)