Cyclocarya paliurus prevents high fat diet induced hyperlipidemia and obesity in Sprague-Dawley rats.

Abstract

Cyclocarya paliurus (CP; qing qian liu), which is used as an herbal tea in China, has been confirmed to have therapeutic effects on hyperlipidemia and obesity, and therefore it is widely consumed to prevent metabolic diseases such as hyperlipidemia and diabetes. In this study, we investigated the preventive effects of CP on obesity and hyperlipidemia, as well as the underlying mechanisms involved in intestinal secretion of apolipoprotein (apo) B48. Sprague-Dawley rats were fed a high-fat diet (HFD) and with or without various concentrations of an ethanol extract of CP (CPE; 2, 4, or 8 g·(kg body mass)(-1)) administered by gavage for 8 weeks. From the results we see that CPE dose-dependently blocked increases in body mass, and decreased food utilization as well as visceral fat mass. Decreased serum levels of total cholesterol, triglycerides, and low density lipoprotein cholesterol, and elevated levels of high density lipoprotein cholesterol, as well as lowered levels of total cholesterol and triglycerides in the liver were also noticed in CPE-treated rats. Magnetic resonance images indicated that the abnormal fat storage induced by the HFD was obviously suppressed by CPE. In addition, ELISA analysis showed reduced fasting serum apoB48 in the CPE treatment groups. Based on the above results, CPE shows a promising preventive effect on obesity and hyperlipidemia, partially through suppressing intestinal apoB48 overproduction.

• Authors: Xiaoming Yao, Zi Lin, Cuihua Jiang, Meng Gao, Qingqing Wang, Nan Yao, Yonglan Ma, Yue Li, Shengzuo Fang, Xulan Shang, Yicheng Ni, Jian Zhang, Zhiqi Yin
• Journal: Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 93 Issue 8 Pg. 677-86 (Aug 2015) ISSN: 1205-7541 [Electronic] Canada
• PMID: 26203820 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Obesity Agents
• Apolipoprotein B-48
• Cholesterol, HDL
• Cholesterol, LDL
• Drugs, Chinese Herbal
• Hypolipidemic Agents
• Triglycerides

Topics

• Adiposity (drug effects)
• Animals
• Anti-Obesity Agents (isolation & purification, pharmacology)
• Apolipoprotein B-48 (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Diet, High-Fat
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drugs, Chinese Herbal (isolation & purification, pharmacology)
• Enzyme-Linked Immunosorbent Assay
• Hyperlipidemias (blood, etiology, physiopathology, prevention & control)
• Hypolipidemic Agents (isolation & purification, pharmacology)
• Intestinal Mucosa (metabolism)
• Intestines (drug effects)
• Intra-Abdominal Fat (drug effects, physiopathology)
• Juglandaceae (chemistry)
• Magnetic Resonance Imaging
• Male
• Obesity (blood, etiology, physiopathology, prevention & control)
• Phytotherapy
• Plant Leaves
• Plants, Medicinal
• Rats, Sprague-Dawley
• Time Factors
• Triglycerides (blood)
• Weight Gain (drug effects)