Abstract | BACKGROUND: The human Y-box-binding protein 1 (YB-1) is a member of the DNA/ RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer. METHODS: Immunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed. RESULTS:
Hormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (≥14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043). CONCLUSION: This suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer.
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Authors | Anbok Lee, Juhyun Woo, Heejung Park, Sun Hee Sung, Ju-Young Seoh, Woosung Lim, Byung-In Moon |
Journal | Breast cancer (Tokyo, Japan)
(Breast Cancer)
Vol. 23
Issue 5
Pg. 685-91
(Sep 2016)
ISSN: 1880-4233 [Electronic] Japan |
PMID | 26193840
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Y-Box-Binding Protein 1
- YBX1 protein, human
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Topics |
- Adult
- Asian People
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(metabolism, mortality, pathology)
- Cytoplasm
(metabolism)
- Female
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Prognosis
- Y-Box-Binding Protein 1
(metabolism)
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