Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients.

Abstract

INTRODUCTION:

Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia.

OBJECTIVE:

Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients.

METHODS:

In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed.

RESULTS:

CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001).

CONCLUSION:

Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk.

• Authors: Daniele Gonçalves Vieira, Beatriz Tavares Costa-Carvalho, Sonia Hix, Rosangela da Silva, Milena S G Correia, Roseli Oselka Saccardo Sarni
• Journal: Annals of nutrition & metabolism (Ann Nutr Metab) Vol. 66 Issue 4 Pg. 237-241 ( 2015) ISSN: 1421-9697 [Electronic] Switzerland
• PMID: 26183722 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2015 S. Karger AG, Basel.

Chemical References

• APOA1 protein, human
• Apolipoprotein A-I
• Biomarkers
• Cholesterol, HDL
• Inflammation Mediators
• Lipids

Topics

• Adolescent
• Adult
• Agammaglobulinemia (blood, immunology, physiopathology)
• Apolipoprotein A-I (blood)
• Biomarkers (blood)
• Body Mass Index
• Brazil (epidemiology)
• Cardiovascular Diseases (epidemiology, etiology)
• Child
• Cholesterol, HDL (blood)
• Common Variable Immunodeficiency (blood, immunology, physiopathology)
• Cross-Sectional Studies
• Down-Regulation
• Female
• Genetic Diseases, X-Linked (blood, immunology, physiopathology)
• Humans
• Inflammation Mediators (blood)
• Lipids (blood)
• Male
• Middle Aged
• Risk
• Up-Regulation
• Young Adult