Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia.

Abstract

AIMS:

To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength.

METHODS:

Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment.

RESULTS:

b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis.

CONCLUSIONS:

b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.

• Authors: Francesco Cacciatore, David Della-Morte, Claudia Basile, Francesco Curcio, Ilaria Liguori, Mario Roselli, Gaetano Gargiulo, Gianluigi Galizia, Domenico Bonaduce, Pasquale Abete
• Journal: Biomarkers in medicine (Biomark Med) Vol. 9 Issue 7 Pg. 669-78 ( 2015) ISSN: 1752-0371 [Electronic] England
• PMID: 26174841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Butyrylcholinesterase

Topics

• Aged
• Aged, 80 and over
• Biomarkers (analysis)
• Body Mass Index
• Butyrylcholinesterase (analysis)
• Female
• Humans
• Linear Models
• Male
• Muscle Strength
• Muscle, Skeletal (physiology)
• Sarcopenia (diagnosis)