Metabolic profiles during an oral glucose tolerance test in pregnant women with and without gestational diabetes.

Abstract

BACKGROUND/AIM:

Gestational diabetes (GDM) is a complex metabolic condition associated with hyperpglycemia that is diagnosed in an oral glucose tolerance test (OGTT) during pregnancy. For a deeper understanding of the pathology of the disease, further investigations during pregnancy are required, ideally under metabolic challenging conditions.

METHODS:

We performed targeted metabolomics in a group of 24 well-matched women during an oral glucose tolerance test (OGTT). 231 plasma metabolites were profiled and compared to conventional clinical diagnostics.

RESULTS:

A pattern of 8 metabolites differed between GDM and healthy controls as early as 30 min in an OGTT (AUC 0.977±0.008), and an increase in acylcarnitine C18:0, decreased concentrations of diacyl phosphatidylcholines (PC aa) C34:4, PC aa C36:4, PC aa C38:5, Lyso PC C20:4 and arachidonic acid were associated with insulin resistance.

CONCLUSION:

Our data suggest an additional value of metabolite pattern in the diagnosis of GDM and describe altered pathways that might be subjected to a more precise diagnosis and individualized therapy.

• Authors: R Lehmann, T Friedrich, G Krebiehl, D Sonntag, H-U Häring, A Fritsche, A M Hennige
• Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 123 Issue 7 Pg. 483-38 (Jul 2015) ISSN: 1439-3646 [Electronic] Germany
• PMID: 26171623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Blood Glucose

Topics

• Adult
• Blood Glucose (metabolism)
• Diabetes, Gestational (metabolism)
• Female
• Glucose Tolerance Test
• Humans
• Insulin Resistance (physiology)
• Metabolome (physiology)
• Pregnancy (metabolism)