Angiotensin receptor blockers: Focus on cardiac and renal injury.

Abstract

Angiotensin II, an important component of renin angiotensin system, is a potent vasopressor and its actions are mostly mediated via angiotensin II type 1 receptor (AT1R) and role of AT2R in counterbalancing the actions of AT1R stimulation are under extensive research. In addition to its physiological actions, angiotensin II plays important roles in the pathogenesis of atherosclerosis, hypertension, left ventricular hypertrophy, and heart failure. The effects of angiotensin II can be blocked by either suppressing its production by blocking angiotensin converting enzyme or by antagonizing its actions on AT1R using angiotensin II receptor blockers (ARBs). Instead of the extensive use of ARBs in the treatment of various cardiovascular diseases, proper selection of a particular ARB is crucial as the clinical condition of individual patient is different and also their economic status would play an essential role in medication compliance. Thus a critical review of the proven and promising actions of ARBs against various pathological conditions will be of great importance for the clinicians as well as for the researchers.

• Authors: Somasundaram Arumugam, Remya Sreedhar, Rajarajan A Thandavarayan, Vengadeshprabhu Karuppagounder, Prasanna Krishnamurthy, Kenji Suzuki, Masahiko Nakamura, Kenichi Watanabe
• Journal: Trends in cardiovascular medicine (Trends Cardiovasc Med) Vol. 26 Issue 3 Pg. 221-8 (Apr 2016) ISSN: 1873-2615 [Electronic] United States
• PMID: 26169314 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• Angiotensin II Type 2 Receptor Blockers
• Receptor, Angiotensin, Type 1
• Receptor, Angiotensin, Type 2
• Angiotensin II

Topics

• Angiotensin II (metabolism)
• Angiotensin II Type 1 Receptor Blockers (adverse effects, therapeutic use)
• Angiotensin II Type 2 Receptor Blockers (adverse effects, therapeutic use)
• Animals
• Drug Interactions
• Drug Therapy, Combination
• Heart (drug effects, physiopathology)
• Heart Diseases (drug therapy, metabolism, physiopathology)
• Humans
• Kidney (drug effects, metabolism, pathology)
• Kidney Diseases (drug therapy, metabolism, physiopathology)
• Myocardium (metabolism)
• Receptor, Angiotensin, Type 1 (drug effects, metabolism)
• Receptor, Angiotensin, Type 2 (drug effects, metabolism)
• Renin-Angiotensin System (drug effects)
• Treatment Outcome